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In 2013, Brand presented and toured his comedy show Messiah Complex, in which he tackled advertising, the laws on drug addiction and the portrayal of his heroes, such as Gandhi, Guevara, Malcolm X and Jesus, and how he is, in comically contrived ways, similar to them. Brand's first presenting role came in 2000 as a video journalist on MTV.
He presented Dancefloor Chart, touring nightclubs in Britain and Ibiza, and hosted the tea-time request show Select.
He also worked as a voice actor in the animated films Despicable Me in 2010, Hop in 2011, and Despicable Me 2 in 2013, and played the title character of the 2011 remake of the romantic comedy Arthur.
In 2013, he released the successful stand-up special Messiah Complex.
Brand was fired several days after coming to work dressed as Osama bin Laden the day after the 11 September 2001 attacks and bringing his drug dealer to the MTV studios.
After leaving MTV, Brand starred in RE: Brand, a documentary and comedy television program that aimed to take a challenging look at cultural taboos.
Beginning his career as a stand-up comedian and later becoming an MTV presenter, Brand first achieved notoriety in 2004 as the host of Big Brother's Big Mouth, a Big Brother spin-off.
When Brand was 8, his mother contracted uterine cancer and then breast cancer one year later.
He returned the following year with Eroticised Humour.
He launched his first nationwide tour, Shame, in 2006.
In a statement, Brand thanked all the producers for "taking the risk of employing an ex-junkie twerp" to front the show.
Of his time presenting the show, he said, "The three years I've spent on Big Brother's Big Mouth have been an unprecedented joy".